Uncovering the particularities of the dynamical interaction between cancer-related Epithelial-Mesenchymal Transition and the Mammalian Cell Cycle: a feedback-based Boolean networks interconnection approach

Epithelial-to-Mesenchymal Transition (EMT) plays a key role in epithelial-cancer. The state trajectory of its underlying Gene Regulatory Network (GRN) includes three fixed-point attractors characterizing epithelial, senescent, and mesenchymal, cell phenotypes, which implies specific cell-to-cell cell-to-tissue interactions. interplay between the GRN driving EMT one regulating Mammalian Cell Cycle (MCC) influences cancer- related growing proliferation. We expose characteristics network arising from interconnection gene regulatory networks associated to MCC. Our purpose is twofold: first, elucidate dynamical properties cancer-related networks. Subsequently, propose computational methodology address cancer. approach based on feedback-based described discrete Boolean terms.